Flights from Des Moines to Boston from $ 257* or from or from$39/mo

Featured daily fares for flights from Des Moines (DSM) to Boston (BOS)

*Prices have been available for round trips within the last 48 hours and may not be currently available. For Economy class, fares listed may be Basic Economy, which is our most restrictive fare option and subject to additional restrictions. Additional baggage charges and fees for other optional service may apply. Other terms and conditions may apply. Schedules are subject to change without notice.